ESTROFEM 2mg. (Oestradiol Valelate) 28 Tablets

Estrofem 2mg. tablets contain oestradiol valerate, used to replace the loss of oestrogen at menopause to relieve symptoms of menopause. Estrofem also stimulates the development of female sexual characteristics for male to female transsexuals in transgender hormone therapy.
 
ESTROFEM 2mg. (Oestradiol Valelate)
Size: 2mg.  28 tablet.
Estrofem 2mg. tablets contain oestradiol valerate, used to replace the loss of oestrogen at menopause to relieve symptoms of menopause. Estrofem also stimulates the development of female sexual characteristics for male to female transsexuals in transgender hormone therapy.
INDICATIONS: oestrogen hormonal therapy
PACKAGE CONTENTS: 1 plastic calendar pack of 28 tablets each with oestradiol valerate 2 mg. in each tablet – total 28 tablets in one box.
DESCRIPTION:
Estrofem 2mg. tablets are an oestrogen hormone replacement therapy (HRT) used to substitute the lack of oestrogen production by the ovaries which occure during menopause or following surgical removal of the ovaries. It is used to relieve symptoms of menopause caused by oestrogen deficiency, such as hot flushes, night sweats, sleeplessness, vaginal dryness, headaches, mood swings, lack of concentration and loss of energy. Estrofem 2mg. tablets are also used to help prevent postmenopausal bone loss (osteoporosis) and reduce risk of fracture. Estrofem stimulates the development of female sexual characteristics, and is used as the oestrogen component of transgender hormone therapy for male to female transsexuals.
Estrofem contains the active ingredient oestradiol valerate, a prodrug (or precursor) of 17 beta-oestradiol, the major and most active form of oestrogen produced by the ovaries, and is used for hormone replacement therapy (HRT).
Estrofem 2mg. tablets substitute for the loss of oestrogen production by the ovaries that occurs during menopause or following surgical removal of the ovaries. Estrofem contains oestradiol, an active form of the female hormone oestrogen that alleviates menopausal symptoms, such as hot flushes, night sweats, sleeplessness, dry vagina, headaches, mood swings, lack of concentration loss of energy and bone loss (osteoporosis).
Estrofem 2mg. tablets can be used as part of a gender reassignment program for male to female transsexuals, by providing a source of oestradiol, the most active form of the female hormone oestrogen. Estrofem 2 mg stimulate the development of female secondary sexual characteristics, such as breast development and also induce metabolic changes such as fat distribution to redefine the general body shape.
Indications: oestrogen hormon replacement therapy
Side effects: the most frequently reported side effects when taking Estrofem tablets 2mg are breast tenderness, breast pain, abdominal pain, nausea, oedema, and headache, skin rash and itching, insomnia and depression. More severe side effects include changes in liver function at higher doses and increased risk of dementia if initiated in women aged 65 or older.
Health risks: long-term HRT with Estrofem does have associated health risks, including an increased risk of breast cancer, endometrial cancer, stroke and deep vein thrombosis. For women with an intact uterus adding a progestogen to an oestrogen replacement regimen like Estrofem for at least 10 days per cycle is recommended to reduce the risk of endometrial cancer.
Contraindications:  you should not use Estrofem 2 mg tablets if you:
are allergic to oestradiol valerate or any ingredients in Estrofem
have a past or family history of carcinoma of the breast, endometrial carcinoma or liver disease
have deep venous thrombosis, thromboembolic disorders, cerebral vascular accident associated with oestrogen use
have abnormal genital bleeding of unknown cause
are pregnant or planning to become pregnant
are taking other medications that may interact with Estrofem, such as anticonvulsants like phenytoin and carbamazepin, barbiturates, anti-infectives like rifampicin, rifabutin, nevirapine, antibiotics like penicillin,.
are a diabetic taking antidiabetics or insulin, without discussion with your doctor, as Estrofem may affect your glucose tolerance
Use and dosage: you should take Estrofem 2 mg tablets with a glass of water once a day, preferably at the same time each day, until all 28 tablets have been taken. The dose you take depends on your condition and should be as recommended by your doctor. When you have finished each pack, start the next pack immediately. You can start taking Estrofem tablets on any convenient day unless you are still having menstrual bleeding, in which case take the first tablet on day 5 of bleeding.
Length of treatment: each pack of Estrofem 2 mg tablets is a calendar pack of 28 tablets. You should take Estrofem tablets 2mg for as long as your doctor recommends.
Missed dose: if you miss a dose of Estrofem 2 mg tablets take it as soon as you remember, unless it is time to take the next dose, then skip the missed dose. Do not take a double dose. If you forget to take a tablet for more than 12 to 24 hours, irregular bleeding may occur.
Package Contents: 1 plastic calendar pack of 28 tablets each with oestradiol valerate 2 mg in each tablet – total 28 tablets in one box.
Active ingredient: oestradiol valerate 2 mg in each tablet
Manufacturer: Novo Nordisk
Storage: keep Estrofem 2mg. 28  tablets in their calendar pack until used. Store at room temperature below 25°C, keep away from direct sunlight and do not refrigerate.